皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展

皮肤T细胞淋巴瘤(cutaneous T cell lymphoma,CTCL)大多属于惰性淋巴瘤,病情进展缓慢,患者确诊时多处于疾病早期。局部用药和物理治疗在CTCL治疗中占重要地位,包括局部外用皮质类固醇激素、免疫抑制剂、维A酸,放疗及光疗等。近年来,有研究对CTCL传统局部用药和物理治疗方法的有效性和安全性进行了重新评估。同时,新型CTCL局部用药和物理治疗策略也不断涌现,如局部外用他扎罗汀、瑞喹莫特,紫外线A联合新型光敏剂的光化学疗法和光动力治疗等。本文对CTCL局部用药和物理治疗的研究进展作一综述。     

Surface modification of TiO2 particles with 12-hydroxy stearic acid and the effect of particle size on the mechanical and thermal properties of thermoplastic polyurethane urea elastomers

The efficient surface modification of titanium dioxide (TiO₂) particles with different sizes was first carried out with “water only method” (Appl. Surf. Sci. 2018, 447, 664–672) developed in our group using 12-hydroxy stearic acid (12-HSA) as the modifier. The 12-HSA-modified TiO₂ particles with different sizes were then used to explore their effect on the mechanical and thermal properties of a thermoplastic polyurethane urea (TPUU) elastomer with superior mechanical and thermal properties produced newly in our lab using nonsymmetric alicyclic diisocyanate and diamine. Orthogonal experimental results showed that the order of impact of each factor on the modification efficiency of TiO₂ particles was: Temperature > time > modifier content. It was found that, in the nanometer (≤100 nm) range, smaller particles were more helpful to enhance the tensile strength of the TPUU elastomer, while larger ones to increase more significantly the elongation at break. Besides, the TiO₂/polyurethane urea nanocomposites exhibited much better thermomechanical performance than the pristine TPUU elastomer, and the thermomechanical performance of the nanocomposites increased with decreasing particle size.     

Mesoporous electroactive silver doped calcium borosilicates: Structural,antibacterial and myogenic potential relationship of improved bio-ceramics

In this work improved electroactive mesoporous Ag-doped bio-ceramics for medical usages are developed, examining their structural, electrical, in-vitro bioactivity, cell cultures and antibacterial properties against various classical pathogenic bacteria. Ag-containing mesoporous bio-ceramics (MBCs): xmol%Ag₂O - (100-x)[45.8CaO-8.4B₂O₃-45.8SiO₂] where x = 2, 5, 7.5 and 10 were synthesized through a sol-gel method. The small angle X-ray scattering and electron microscopy studies reveal the embedment of silver nanoparticles in the samples. Existence of silver as Ag⁺/Ag⁰ forms in the samples is confirmed by X-ray photoelectron spectroscopy. The N₂ adsorption-desorption analysis evidence the mesoporous structure of the samples. The electrical conductivity of samples increases from 5.4 x 10^?8 S cm^?1 for x = 2 to 1.9 x 10^?6 S cm^?1 for x = 7.5 and then decreases to 0.9 x 10^?6 S cm^?1 for x = 10 at 110 °C. In vitro bioactivity studies revealed that Ag-containing MBCs hold the bone-like hydroxyapatite formation after immersion in human blood plasma like-solution such as Dulbecco's Modi?ed Eagle's Medium. The antibacterial effect of samples against pathogenic bacteria (S. aureus, E. coli, P. monas aeruginosa, and B. cereus) increases with Ag concentration (x = 7.5) and then decreases with Ag content (x = 10). Antibacterial effect is greater for the sample with high electrical conductivity. The cell culture studies evidence not considerable cytotoxic effects for Ag-containing MBCs. Finally, the C2C12 myoblast cell culture studies reveal the significant cell growths and differentiation (myogenesis) for high electrical conducting Ag-containing MBCs.     

Effect of hydrothermal aging on dental multilayered zirconia for monolithic restorations: An in vitro study

The aim of this in vitro study was to investigate the changes in mechanical, optical, and surface properties of multilayered zirconia during hydrothermal aging.One conventional block (Katana Zirconia HT) and three multilayered blocks (Katana Zirconia ML, STML, and UTML) of monolithic zirconia were examined. Bar-shaped specimens were autoclaved at 134°C and 0.2MPa for 0, 5, and 10 h. The Young's modulus, three-point flexural strength, and nanoindentation hardness were measured to evaluate the mechanical properties. The surface roughness, phase distribution, surface microstructure, and elemental composition were measured to analyze the surface properties. The contrast ratio and total transmittance were measured via spectrophotometry to evaluate the optical properties. Statistical differences were analyzed using appropriate ANOVA, Tukey HSD post hoc tests, and independent and paired sample t-tests (α = .05).The monoclinic phase increased gradually after hydrothermal aging. The yttrium and zirconium concentrations decreased, and the oxygen concentration and the surface roughness increased in all specimens (P<.05) after the aging process. All specimens showed significant grain push-out and microcracks. The total transmittance increased, and the contrast ratio and Young's modulus decreased in all specimens (P<.05) after the aging process. The nanoindentation hardness and three-point flexural strength exhibited a decreasing tendency after the aging process. However, there were no statistical differences (P>.05) between the materials. Significant interactions between material grades and hydrothermal aging were found for all the properties studied (P<.001).Microstructural alterations and significant phase transformations were detected on the surface of the multilayered zirconia after hydrothermal aging. The hydrothermal aging led to increased surface roughness, opaqueness, and elasticity of multilayered zirconia. The optical, mechanical, and surface properties of multilayered zirconia were influenced by the grade of the material after hydrothermal aging. Careful consideration of the grade of materials is necessary for the appropriate selection of multilayered zirconia ceramics for monolithic restorations.     

Preparation and characterization of Cf/Pollucite composites through geopolymer precursors

Continuous carbon-fibre-reinforced Cs-geopolymer composite (C_f/CsGP) were prepared, and its in-situ conversion was investigated during high-temperature treatments. The effect of treatment temperature on the thermal evolution process and mechanical properties of the resulting products were systematically evaluated. The results indicated that the crystallization temperature of C_f/CsGP composite was considerably delayed because the amorphous structure of carbon fibres was not conducive as a nucleation substrate for pollucite derived from the CsGP matrix. Moreover, the integrity of the corresponding resulting products derived from the C_f/CsGP composite were damaged due to thermal shrinkage that occurred during the high-temperature treatment process. When treatment temperature was ≤1200^oC, the mechanical properties of the corresponding products exhibited an upward trend, which was ascribed to the improvement of the densification degree of the resulting composite and well interface-bonding state between carbon fibres and pollucite. However, the mechanical properties of the resulting composites decreased with the treatment temperature continued increased from 1200 to 1400^oC. This phenomenon was attributed to the impairment of fibre properties caused by interfacial reactions.     

混菌矿化增强再生粗骨料的物理力学性能

为克服单一微生物培养成本高且矿化鲁棒性不足的缺陷，提出了一种混菌矿化增强再生粗骨料物理力学性能的方法.通过筛选矿化效率较高的好氧嗜碱混菌，考察了混菌矿化对再生粗骨料物理力学性能和混凝土抗压强度的影响.结果表明：相同增强时间下，混菌比纯菌呈现出更优异的矿化增强效果；随着混菌矿化增强时间的延长，再生粗骨料吸水率和压碎指标呈现出先减小后增大的趋势，最优增强时间为15 d；采用矿化增强再生粗骨料制备的再生混凝土抗压强度提高幅度达到22.1%.     

基于STM32单片机的大学生体能监测仪设计与实现

体能监控仪作为生命体征监测设备,对于辅助大学生完成体能训练有很大帮助;基于STM32单片机技术,设计开发集成了多种传感器的一种大学生体能监测装备,它能够有效的检测包括心率检测、人体的步数、运动圈速、消耗卡路里等信息;该设计采用了STM32作为主控芯片,采用模块化的设计思路;在系统硬件设计方面,设计了包括STM32控制系统、心率获取电路、三轴传感器电路、显示电路以及按键电路等;同时将软件模块拆分成了初始化子程序、心率获取子程序,步数获取子程序,显示子程序等;Proteus仿真结果显示,使用STM32单片机技术设计的体能监测系统,能够运行稳定,测量心率范围60次/min~180次/min,可在心率异常时报警,同时检测步数的准确率达98%,满足体能监测任务需要,实验结果符合预期;为STM32单片机在体育运动研究信息化中应用提供参考。     

Structural breakdown of starch-based foods during gastric digestion and its link to glycemic response: In vivo and in vitro considerations

The digestion of starch-based foods in the small intestine as well as factors affecting their digestibility have been previously investigated and reviewed in detail. Starch digestibility has been studied both in vivo and in vitro, with increasing interest in the use of in vitro models. Although previous in vivo studies have indicated the effect of mastication and gastric digestion on the digestibility of solid starch-based foods, the physical breakdown of starch-based foods prior to small intestinal digestion is often less considered. Moreover, gastric digestion has received little attention in the attempt to understand the digestion of solid starch-based foods in the digestive tract. In this review, the physical breakdown of starch-based foods in the mouth and stomach, the quantification of these breakdown processes, and their links to physiological outcomes, such as gastric emptying and glycemic response, are discussed. In addition, the physical breakdown aspects related to gastric digestion that need to be considered when developing in vitro–in vivo correlation in starch digestion studies are discussed. The discussion demonstrates that physical breakdown prior to small intestinal digestion, especially during gastric digestion, should not be neglected in understanding the digestion of solid starch-based foods.     

Microstructure and hydrogen storage properties of Ti–V–Cr based BCC-type high entropy alloys

In this work, the crystal structure and hydrogen storage properties of V₃₅Ti₃₀Cr₂₅Fe₁₀, V₃₅Ti₃₀Cr₂₅Mn₁₀, V₃₀Ti₃₀Cr₂₅Fe₁₀Nb₅ and V₃₅Ti₃₀Cr₂₅Fe₅Mn₅ BCC-type high entropy alloys have been investigated. It was found that high entropy promotes the formation of BCC phase while large atomic difference (δ) has the opposite effect. Among the four alloys, the V₃₅Ti₃₀Cr₂₅Mn₁₀ alloy shows the highest hydrogen absorption capacity while the V₃₅Ti₃₀Cr₂₆Fe₅Mn₅ alloy exhibits the highest reversible capacity. The cause of the loss of desorption capacity is mainly due to the high stability of the hydrides. The higher room-temperature desorption capacity of the V₃₅Ti₃₀Cr₂₅Fe₅Mn₅ alloy is due to higher hydrogen desorption pressure. After pumping at 400 °C, the hydrides can return to the original BCC structure with only a small expansion in the cell volume.     

庄旺煤矿综放工作面顶煤冒放性分析

结合庄旺煤矿50208综放工作面煤层赋存特征,系统分析了开采深度、煤层强度、煤层厚度、煤层夹矸、煤层顶板及顶煤节理裂隙对综放工作面顶煤冒放性的影响,并通过隶属度法对庄旺煤矿顶煤冒放性的影响因素进行计算,做出综合评价,最终计算得工作面顶煤冒放性隶属度值μ为0.701,冒放等级为中等。因此,庄旺煤矿采用综采放顶煤回采工艺是可行的。